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This pore is rimmed with several structurally conserved carbonyl oxygens in addition to the hydroxyl group of the invariant tyrosine from the carboxyl terminus of the SET area (Figure 1 ). Mutation of Tyr245 or Tyr305 lawyers in my area SET7/9 (Figure 4b ) alters its specificity from an H3 K4 mono-methylase to a tri- a...