The exception to the rule is the DOT1 household, members of which methylate K79 within the globular region of histone H3 and which are structurally not related to SET-domain proteins four - 6 Current work suggests that SET-area-containing proteins methylate a few proteins along with histones (see later); they need to subsequently be named protein lysine methyltransferases somewhat than histone lysine methyltransferases.
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